Cyber-Physical Systems (CPS) are the set of systems located at the border of digital and physical systems, which puts them in a central and essential position for the development of intelligent ecosystems. These intelligent ecosystems are characterized by the openness, heterogeneity, dynamics and ubiquity of the entities that constitute them. Given the sensitivity and central role of CPS, their robustness (security & reliability) as well as their optimization and decision-making efficiency ("intelligence") become a major issue in their design and development. The problematic of this project is then to investigate and exploit technological and methodological levers to reinforce the robustness of intelligent CPS.